Speakers are very personal choice - what one person likes, another may not. however the question was : any difference in sound.
The answer is yes, because all speakers are different. However does being active make them necessarily better? No.
What active speakers do allow is the tuning of the speaker to give a certain frequency response despite the size of the speaker. Normally a speaker the shape and size of the BL6000 would be unable to produce low frequencies. The amplifier in this case is tweaked to allow this. A passive speaker is made assuming that the signal sent will be a flat response and has to therefore produce a flat output - or as close as it can. That is why passive speakers are on the whole larger for a similar bass response.
I actually don't like S80s much but I do like S45.2s and M100s. I would have these rather than most of the Beolab range. However they need a reasonable system to accompany them.
BL4000s are really rather good and often forgotten.